Mehmet Cansev Selected Research

Cytidine Diphosphate Choline (Citicoline)

12/2021	Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally - Induced endotoxic shock.
1/2020	Effects of CDP-choline administration on learning and memory in REM sleep-deprived rats.
2/2016	CDP-choline modulates matrix metalloproteinases in rat sciatic injury.
1/2014	Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury.
7/2013	CDP-choline reduces severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis.
7/2013	Cytidine 5'-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model.
1/2012	Prevention of epidural fibrosis in rats by local or systemic administration of citicoline.
6/2010	Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia.
5/2003	Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation.

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Mehmet Cansev Research Topics

Disease

7	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 05/2006
5	Endotoxemia 12/2021 - 09/2009
5	Inflammation (Inflammations) 01/2021 - 10/2012
4	Sepsis (Septicemia) 01/2021 - 09/2009
4	Brain Injuries (Brain Injury) 12/2020 - 05/2013
4	Hyperoxia 12/2020 - 07/2013
3	Peripheral Nerve Injuries 12/2021 - 01/2014
3	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2017 - 05/2013
3	Parkinson Disease (Parkinson's Disease) 12/2016 - 11/2008
3	Fibrosis (Cirrhosis) 01/2015 - 01/2012
2	Hypotension (Low Blood Pressure) 12/2021 - 05/2003
2	Septic Shock (Toxic Shock Syndrome) 12/2021 - 09/2009
2	Shock 12/2021 - 05/2003
2	Cicatrix (Scar) 02/2016 - 01/2014
2	Infarction (Infarctions) 01/2015 - 05/2013
2	Brain Infarction 01/2015 - 05/2013
2	Lung Injury 01/2015 - 07/2013
1	Parvoviridae Infections (Parvovirus Infection) 01/2021
1	Brain Diseases (Brain Disorder) 01/2020
1	Sleep Deprivation 01/2020
1	Memory Disorders (Memory Loss) 01/2020
1	Premature Birth (Birth, Premature) 12/2017
1	Parkinsonian Disorders (Parkinsonism) 12/2016
1	Acute-Phase Reaction 11/2016
1	Dyskinesias (Dyskinesia) 08/2015
1	Lung Diseases (Lung Disease) 01/2015
1	Weight Gain 01/2015
1	Retinopathy of Prematurity (Retrolental Fibroplasia) 09/2014
1	Disease Progression 09/2013
1	Body Weight (Weight, Body) 07/2013
1	Necrotizing Enterocolitis 07/2013
1	Foreign-Body Reaction 01/2012
1	Bradycardia 06/2010
1	Disseminated Intravascular Coagulation 06/2010
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2006

Drug/Important Bio-Agent (IBA)

9	Cytidine Diphosphate Choline (Citicoline)IBA 12/2021 - 05/2003
8	UridineIBA 12/2021 - 09/2006
8	Choline (Choline Chloride)IBA 12/2021 - 05/2003
6	Phospholipids (Phosphatides)FDA LinkGeneric 01/2017 - 05/2006
3	AntioxidantsIBA 12/2020 - 01/2017
3	Membrane Proteins (Integral Membrane Proteins)IBA 01/2015 - 05/2006
3	Caspase 3 (Caspase-3)IBA 01/2015 - 05/2013
2	C-Reactive ProteinIBA 01/2021 - 11/2016
2	ButyrylcholinesteraseIBA 01/2021 - 10/2012
2	Oxygen (Dioxygen)IBA 12/2020 - 12/2017
2	CytidineIBA 01/2020 - 09/2006
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 01/2015
2	Fortasyn ConnectIBA 01/2015 - 09/2013
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2015 - 01/2015
2	Histones (Histone)IBA 01/2015 - 01/2015
2	EndotoxinsIBA 06/2010 - 09/2009
2	Cholinergic Agents (Cholinergics)IBA 06/2010 - 05/2003
1	Cholinesterases (Cholinesterase)IBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2020
1	Oxidants (Oxidizing Agents)IBA 12/2020
1	Biological ProductsIBA 01/2020
1	Extracellular Matrix ProteinsIBA 01/2018
1	IronIBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	Saline SolutionIBA 12/2017
1	Vitamin E FDA LinkGeneric 01/2017
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2017
1	SeleniumIBA 01/2017
1	Peptides (Polypeptides)IBA 12/2016
1	Heparitin Sulfate (Heparan Sulfate)IBA 12/2016
1	Dopamine (Intropin)FDA LinkGeneric 12/2016
1	Laminin (Merosin)IBA 12/2016
1	Therapeutic UsesIBA 12/2016
1	Immunoglobulins (Immunoglobulin)IBA 11/2016
1	Immunoglobulin G (IgG)IBA 11/2016
1	Immunoglobulin M (IgM)IBA 11/2016
1	Alanine Transaminase (SGPT)IBA 11/2016
1	NitrogenIBA 11/2016
1	CreatinineIBA 11/2016
1	Creatine Kinase (Creatine Phosphokinase)IBA 11/2016
1	Matrix Metalloproteinases (MMPs)IBA 11/2016
1	Urea (Carbamide)FDA LinkGeneric 11/2016
1	VitaminsIBA 09/2016
1	Levodopa (L Dopa)FDA LinkGeneric 08/2015
1	Carbidopa (Lodosyn)FDA LinkGeneric 08/2015
1	Environmental BiomarkersIBA 01/2015
1	Valproic Acid (Depakote)FDA LinkGeneric 01/2015
1	Histone Deacetylase InhibitorsIBA 01/2015
1	SelectinsIBA 09/2014
1	CytokinesIBA 07/2013
1	Neuroprotective AgentsIBA 05/2013
1	Aryldialkylphosphatase (Paraoxonase)IBA 10/2012
1	EnzymesIBA 10/2012
1	Dacarbazine (DIC)FDA LinkGeneric 06/2010
1	Hemostatics (Antihemorrhagics)IBA 06/2010
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 09/2009
1	LipidsIBA 09/2009
1	Docosahexaenoic AcidsIBA 11/2008

Therapy/Procedure

3	Injections 12/2017 - 07/2013